The approach taken by the authors is intuitive and practical, without sacrificing sufficient detail in the discussion of the methods and algorithms in the program. In this chapter we discuss avariety ofmethods to handle missing data, including some relativelysimple approaches that can often yield reasonable results. Auxiliary variables in multiple imputation in regression with. Statistical methods for addressing missing values have been actively pursued in recent years, including maximum likelihood ml estimation, bayesian estimation and multiple imputation mi, all of which are based on the assumption that data are missing at random mar. Multiple imputation of missing data using sas kindle edition. Multiple imputation of missing covariate values in multilevel. Missing data takes many forms and can be attributed to many causes. Multiple imputation using chained equations for missing. Mi is becoming an increasingly popular method for sensitivity analyses in order to assess the impact of missing data. For more information on what makes missing data ignorable, see my article, missing data mechanisms. A simulation study of a linear regression with a response y and two predictors x1 and x 2 was performed on data with n 50, 100 and 200 using complete cases or multiple imputation with 0, 10, 20, 40 and 80.
It offers practical instruction on the use of sas for multiple imputation and provides numerous examples that use a variety of public release data sets. Multiple imputation for missing data in epidemiological and. Flexible imputation of missing data, second edition crc. Multiple imputation is available in sas, splus, and now spss 17.
Software using a propensity score classifier with the approximate bayesian boostrap produces badly biased estimates of regression. Ignorable missingdata mechanism let y be the n p matrix of complete data, which is not fully observed, and denote the observed part of y by obs and the missing part by y mis. A few options for treating missing data in multilevel models are available in standard statistical software. Published in sociological methods and research 28 february 2000. A quantitative analysis is then provided to confirm the hypothesis that modelbased multiple imputation is an enhancement over traditional missing data approaches to reject inference. The authors aim is to clarify the issues raised by missing data, describing the rationale for mi, the relationship between the various imputation models and associated algorithms and its application to increasingly complex data structures. A statistical programming story chris smith, cytel inc. The authors aim is to clarify the issues raised by missing data. Software using a propensity score classifier with the approximate bayesian boostrap produces badly biased estimates of regression coefficients when data on predictor.
Multiple imputation mi appears to be one of the most attractive methods for general purpose handling of missing data in multivariate analysis. Sourcereference the ideas for this paper originated from research work on david j. More precisely, we imputed missing variables contained in the student background datafile for tunisia one of the timss 2007 participating countries, by using van buuren, boshuizen, and knooks sm 18. Theoretical considerations as well as simulation studies have shown that the inclusion of auxiliary variables is generally of benefit.
When substituting for a data point, it is known as unit imputation. Multiple imputation of missing data using sas kindle edition by berglund, patricia, heeringa, steven g download it once and read it on your kindle device, pc, phones or tablets. The mice method includes filling in some random value at start. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The package provides four different methods to impute values with the default model being linear regression for. Auxiliary variables in multiple imputation in regression. Multiple imputation of missing data using sas, berglund. A cautionary tale multiple imputation for missing data. Multiple imputation provides several benefits over single imputation techniques, such as mean imputation of missing data, as it provides better estimates of standard errors allison, 2000. Allison university of pennsylvania address correspondence to paul d. This article presents a simulation and data analysis case study using a method for dealing with missing data, multiple imputation, that allows for valid statistical. Instead of filling in a single value for each missing value, rubins 1987 multiple imputation procedure replaces each missing value with a set of plausible values that represent the uncertainty about the right value to impute.
Missingdata imputation missing data arise in almost all serious statistical analyses. Multiple imputation is a simulationbased statistical technique for handling missing data. There are three main problems that missing data causes. Another way of dealing with missing data is to use the amelia package. Missing values analysis and data imputation overview 6 spss 6 sas 7 stata 8 data examples in this volume 8 key concepts and terms 9 causes of nonresponse 9 item nonresponse 9 listwise deletion of cases with missing values 10 types of missingness 11 missing completely at. The statistical model behind pan, which we will refer to as the pan. Like many before me have mentioned, it is not for the wide audience, although one could gather that from the title alone, but even within the circles of multiple imputation mi, certain people will struggle to come to terms with all. Multiple imputation of missing data using sas available in paperback, nook book.
Download citation multiple imputation for missing data. Multiple imputation for missing data statistics solutions. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing data problem. A cautionary tale, sociological methods and research, 28, 309. Ignorable missing data mechanism let y be the n p matrix of complete data, which is not fully observed, and denote the observed part of y by obs and the missing part by y mis. Jun 29, 2009 multiple imputation has potential to improve the validity of medical research. Multiple imputation is becoming increasingly popular. Multiple imputation of missing covariate values in. The following is the procedure for conducting the multiple imputation for missing data that was created by rubin in 1987. In this paper, we document a study that involved applying a multiple imputation technique with chained equations to data drawn from the 2007 iteration of the timss database. For example, in data derived from surveys, item missing data occurs when a respondent elects not to answer certain questions, resulting in only a dont know or refused. Multiple imputation of missing data using sas by patricia. We use as a running example the social indicators survey, a telephone survey of new york city families.
It provides both theoretical background and practical solutions for those working with incomplete data sets in an engaging. Creating a good imputation model requires knowing your data very well and having variables that will predict missing values. Jun 19, 2019 introduce multiple imputation for statistical analysis with missing data compare and contrast this with other methods, in particular inverse probability weighting and doubly robust methods, and to introduce accessible methods for exploring the sensitivity of inference to the missing at random assumption. These approaches are especially useful when the data contain many. The validity of results from multiple imputation depends on such modelling being done carefully and appropriately. Impute missing values using an appropriate model that incorporates random variation. Multiple imputation for missing data in epidemiological. Because it has to be done on cases present in the data by definition, where there is a systematic bias in the missing cases the present cases may not be very.
Instead of filling in a single value for each missing value, rubins 1987 multiple imputation procedure replaces each missing value with a set of plausible values that represent the uncertainty about the right value to. Multiple imputation using chained equations for missing data. Sourcereference the ideas for this paper originated. An imputation generally represents one set of plausible values for missing data multiple imputation represents multiple sets of plausible values. Software using a propensity score classifier with the approximate bayesian bootstrap produces badly biased estimates of regression coefficients when data on predictor variables are missing at random or missing completely at random. A recent bmj article reported the development of the qrisk tool for cardiovascular risk prediction, based on a large general practice research database. If there is a high percentage of missings and theyre not missing at random, you may get biased estimates for the imputation.
Using multiple imputations helps in resolving the uncertainty for the missingness. This is certainly a very comprehensive book on missing data imputation, but one that is equally hard to follow. This book focuses on a particular statistical method for analysing and drawing inferences from incomplete data, called multiple imputation mi. Two algorithms for producing multiple imputations for missing data are evaluated with simulated data. The imputation function is the amelia function, which creates new data sets. Use features like bookmarks, note taking and highlighting while reading multiple imputation of missing data using sas. However, the multiple imputation procedure requires the user to model the distribution of each variable with missing values, in terms of the observed data.
The basic idea, first proposed by rubin 1977 and elaborated in his 1987 book, is quite simple. Multiple imputation has potential to improve the validity of medical research. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missingdata problem. Multiple imputation is rather easy to carry out in practice, and can be used in virtually any missing data problem. As the name suggests, mice uses multivariate imputations to estimate the missing values. Paul allisons home page university of pennsylvania. Statistical analysis with missing data using multiple. In statistics, imputation is the process of replacing missing data with substituted values. Jonathan sterne and colleagues describe the appropriate use and reporting of the multiple imputation approach to dealing with them missing data are unavoidable in epidemiological and clinical research but their potential to undermine the validity of research results has often been overlooked in the medical literature. A cautionary tale two algorithms for producing multiple imputations for missing data are evaluated with simulated data. The sas multiple imputation procedures assume that the missing data are missing at random mar, that is, the probabilitythat an observation is missing may dependon y obs. How to identify and impute multiple missing values using r. Multiple imputation by fully conditional specification for. When and how should multiple imputation be used for.
Regarding the problem of x2 being missing at the time of imputation mice actually never feeds missing values into the x data. For example, id like the imputed variable x1 to be greater or equal to the sum of my two other variables, say x2 and x3. This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the mice package as developed by. A cautionary tale multiple imputation online is not updated for a while, but this website is still have some useful linkages. I would like to use imputation for replacing missing values in my data set under certain constraints. Graham, 2012 and is easily accessible through the statistical software r r development core team, 2014. Missing rates and multiple imputation cross validated. Multiple imputation for missing data is an attractive method for handling missing data in multivariate analysis.
Thermuohp biostatistics resource channel 210,305 views 45. When and how should multiple imputation be used for handling. Multiple imputation of missing data using sas provides both theoretical background and constructive solutions for those working with incomplete data sets in an engaging exampledriven format. Basically, multiple imputation makes all your model parameter estimates less certain as a function of the accuracy with which the missing data can be predicted with your imputation model, which will depend, among other things, on the amount of missing that needs imputing, and the number of imputations you use. Mi is attractive because it is both practical and widely applicable. Further, as we will see, it can be used for both \ignorable and. In a 2000 sociological methods and research paper entitled multiple imputation for missing data. Multiple imputation as a missing data approach to reject. Multiple imputation provides a useful strategy for dealing with data sets with missing values. The chainpart of the imputation limits the impact from this initial value. Multiple imputation in a nutshell the analysis factor. The mice package in r is used to impute mar values only. The report also summarizes how to carry out multiple imputation and maximum likelihood using sas and stata. How to use spssreplacing missing data using multiple imputation regression method duration.
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